Enterprise Server for .NET uses a REST web service to implement the EXCI feature, so in order to use EXCI you must add its REST configuration to the region.
EXCI uses REST to invoke the mirror transaction CPMI. It uses a binary commarea which needs to be large enough for the response returned by any transaction you will invoke, plus XXXX bytes of overhead.
The EXCI client class gets the URL for the REST request from its EXCI client configuration, as explained in Configuring EXCI, so you can use the URL path of your choice for the service configuration. Assuming you use /rest/exci, and your largest EXCI response is under 3KB, you might configure a REST service with these parameters:
See To Configure a REST Web Service for more information.